AV Fistula Application for Bioabsorbable Magnesium

Hemodialysis is the most common procedure to sustain life for patients with End Stage Renal Disease. The almost 500k patients in the U.S. that receive treatment require vascular access to enable dialysis. The Arterial-Venous (AV) Fistula is the preferred access method.

The nanoVascular team has developed a novel device, the BioFlow Absorbable Vascular Scaffold, to address the high failure rate of the current AV fistula procedure used to facilitate hemodialysis.

The AV Fistula Procedure

hemodialysis illustration

In an AV Fistula procedure, a surgeon clips a vein in the patient’s arm and routes it to a nearby artery to create a high-flow long-term access point for the IV needles to integrate into the patient’s circulatory system.

Unfortunately, this traditional method is burdened with a failure rate of approximately 50 percent. Failures have been attributed to turbulent blood flow which can be induced when an acute (less than 90 degrees) arterial-venous angle is implemented for the fistula.

There is a significant need to increase the success rate of this critical procedure.

A Better Option: AV Fistula + BioFlow + Obtuse Angle = Laminar Blood Flow

hemodialysis illustration

The BioFlow device is a novel stent-like structure that provides intraoperative support to the delicate vein as the surgeon sutures it to the nearby artery.

Made from BioMg® 250, a patented absorbable magnesium alloy, the BioFlow implant allows the surgeon to form the vein with a smooth obtuse (greater than 90 degrees) arterial-venous angle to reduce turbulence and create a laminar blood flow.

We estimate that the use of the BioFlow device will reduce fistula complications by up to 50%.

Simple and Effective

BioFlow device with applicator

The BioFlow device can be used in standard open AV fistula procedures.

The device is provided sterile and pre‑assembled to its disposable insertion instrument. It takes only moments to deploy.

The device is naturally absorbed by the body after it has served its function.